刘玮玮,李攀,李浩,等.数字光处理技术成形β-磷酸三钙生物陶瓷及其生物学评价[J].精密成形工程,2023,15(11):69-75.
LIU Wei-wei,LI Pan,LI Hao,et al.Fabrication of β-tricalcium Phosphate Bioceramics by Digital Light Processing Technique and Its Biological Evaluation[J].Journal of Netshape Forming Engineering,2023,15(11):69-75. |
| 数字光处理技术成形β-磷酸三钙生物陶瓷及其生物学评价 |
| Fabrication of β-tricalcium Phosphate Bioceramics by Digital Light Processing Technique and Its Biological Evaluation |
| 投稿时间：2023-10-07 |
| DOI：10.3969/j.issn.1674-6457.2023.011.008 |
| 中文关键词: 数字光处理 3D打印 β-磷酸三钙 生物陶瓷 生物学性能 |
| 英文关键词: digital light processing 3D printed β-tricalcium phosphate bioceramics biological properties |
| 基金项目:陕西省重点研发计划重点产业创新链项目(2017KTZD6-01);陕西省科技统筹创新工程计划(2016KTZDGY4-06) |
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| 中文摘要: |
| 目的 研究数字光处理技术(Digital Light Processing，DLP)打印β-磷酸三钙(Beta-Tricalcium Phosphaye，β-TCP)生物陶瓷的成形性能与生物学性能。方法 通过表面活性剂硬脂酸改性β-TCP粉体，将改性后的β-TCP粉体与丙烯酸类及甲基丙烯酸类树脂均匀混合成3D打印浆料，进行3D打印性能研究。采用X射线衍射仪(X-Ray Diffraction，XRD)、接触角测量仪、数字式黏度计表征β-TCP粉体、浆料及3D打印支架性能，并进行体外细胞试验研究β-TCP多孔支架的生物学性能。结果 粉体XRD结果显示，硬脂酸改性β-TCP粉体并未影响原始粉体的物相组成;而表面活性剂硬脂酸降低了树脂与粉体表面的接触角，提高了粉体与树脂的亲和性。3D打印β-TCP浆料的固含量为48%(体积分数)，在常温下，黏度仅为2.91 Pa.s。支架XRD结果显示，3D打印β-TCP多孔支架的主要物质仍为β-TCP，仅有部分转化为α-TCP。体外细胞试验表明，3D打印β-TCP支架表面可黏附大量细胞，培养7 d后，细胞延伸至支架孔隙内，同时其溶血性结果较钛合金(Ti6Al4V)及聚醚醚酮(PEEK)的优异。结论 3D打印β-TCP多孔支架可作为骨替代植入物，为治疗临床骨缺损疾病提供新途径。 |
| 英文摘要: |
| The work aims to study the formability and biological properties of β-Tricalcium Phosphate (β-TCP) bioceramics printed by digital light processing (DLP) technique. β-TCP powder modified by surfactant stearic acid was evenly mixed with acrylic resins and methacrylic resin to form 3D printed slurry, and then the 3D printed process was verified. An X-ray diffractometer (XRD), a contact Angle measuring instrument, and a digital viscometer were used to characterize the properties of β-TCP powder, slurry and 3D printed scaffolds. The biological properties of β-TCP porous scaffolds were studied by cell and animal experiments. The powder XRD results showed that the modification of β-TCP powder did not affect the phase composition of the powder. The surfactant stearic acid reduced the contact angle between the resin and the powder surface, and improved the affinity between the powder and the resin. The solid content of 3D printed β-TCP slurry was 48vol.% and the viscosity was only 2.91 Pa.s at room temperature. The scaffold XRD results showed that the main substance of sintered scaffold was β-TCP, and part of it was transformed into α-TCP. In vitro cell experiments showed that the surface of 3D printed β-TCP scaffolds could adhere to a large number of cells. After 7 days of culture, the cells extended into the pores of the scaffold. And the hemolytic results were better than those of Ti6Al4V and PEEK. 3D printed β-TCP porous scaffolds can be used as bone replacement implants, providing a new way to treat clinical bone defect diseases. |
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